A Canadian research review found that the evidence on puberty blockers and cross-sex hormones for transgender youth is of very low certainty, making it impossible to conclude whether the treatments are beneficial or harmful. Altough there a safety concerns, Canada continues to follow a gender-affirming care model.
The study, funded by McMaster University and SEGM, found weak evidence suggesting potential benefits for quality of life and depression in some cases but lacked reliable data on long-term effects, suicide rates, or physical harm. Researchers stress that doctors must clearly communicate these uncertainties to patients and caregivers and consider whose values guide treatment decisions.
Concerns remain over puberty blockers potentially "locking in" gender identity, fertility risks, and possible effects on brain development. While once considered fully reversible, questions about their long-term impact persist.
Compiled from: Sharon Kirkey, "Considerable uncertainty' remains about gender treatments for kids, Canadian researchers warn,” National Post, Jan. 24, 2025.